SOP for Performance Check of Karl Fischer
1.0 OBJECTIVE
To calibrate the equipment for reliable and accurate results.
2.0 SCOPE
This procedure is applicable for Karl Fischer apparatus installed in the quality control department.
3.0 RESPONSIBILITY
3.1 Doing: Technical Assistant/ Executive
3.2 Checking: Executive /Manager
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4.0 ACCOUNTABILITY
Head of the Department
5.0 PROCEDURE
5.1 For Linearity and accuracy:
5.1.1 Frequency of the calibration: Monthly
5.1.2 Weigh accurately about 50, 100, 150, 200, 250 mg of Disodium Tartarate.
5.1.3 Perform the titration using the KF reagent as per the S.O.P.
5.1.4 Note the Burette reading and the water content.
5.1.5 Report the results in the given format as per Annexure-I
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5.1.6 Check the linearity and correlation coefficient.
5.1.1 Linearity should not be less than 99.0%
5.1.2 Correlation coefficient should not be less than 0.9900%.
5.1.3 The performance of the instrument is satisfactory if the obtained Linearity and Correlation coefficient is within the given limit.
5.2 Burette calibration:
5.2.1 Frequency of the calibration: Once in 3 Months
5.2.2 Use water for calibration.
5.2.3 Mount the burette tip firmly on the stand rod, it must not be moved during the test.
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5.2.4 Set dispensing and filling rate of the burette to ‘max’
5.2.5 Take a dried beaker and tare the beaker.
5.2.6 Discharge the volume into the beaker and note volume dispensed.
5.2.7 Press <FILL> Key.
5.2.8 Weigh the dispensed volume.
5.2.9 Repeat 5 discharges of different volume.
5.2.10 Calculate the actual volume
5.2.11 Note down the reading in the provided format Annexure – I
5.2.12 Maximum relative error of the 10 ml exchange unit should NMT 0.5%.
5.2.13 The performance of the burette is satisfactory if the obtained relative error is within the limit.
5.3 If the performance is not satisfactory then follow S.O.P.
6.0 ABBREVIATION
6.1 % = Percentage
6.2 ml = Millilitre
6.3 mg = Milligram
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