Tablet Dissolution Test in Different Stages (S1, S2 and S3)
Dissolution test is done to verify the release of drug in the solution from the tablet because of binders, granulation, mixing and the coating may affect the release of drug from tablets.
The amount of dissolved active ingredient is known as Q in the dissolution test. The limit of Q may be different in different monographs according to the nature of the formulation and its active ingredients. Dissolution test is done using 6 units or dosage forms.
[ads id="ads1"]
Dissolution Test
These dosages forms are run for the specified time period, sampled and analyzed for the dissolved amount of active ingredient in percentage. This is the first stage of the dissolution and known as S1 Stage.
In S1 stage dissolved amount of each unit should not be less than Q+5%. It shows that every unit should be above 5% of the specified limit in the individual monograph. If any of the units is found below this limit then we have to analyze the sample in the S2 stage.
[ads id="ads1"]